Cortical Development and Plasticity • Dynamics • Brain Disorders
The Sur laboratory studies the development, plasticity and dynamics of circuits in the cerebral cortex of the brain. The laboratory’s goal is to discover fundamental mechanisms of brain wiring and processing, and how they go awry in disorders of brain development.
Some recent papers from our Lab:
- Mellios, N., D.A. Feldman, S.D. Sheridan, J.P.K. Ip, S. Kwok, S.K. Amoah, B. Rosen, B.A. Rodriguez, B. Crawford, R. Swaminathan, S. Chou, Y. Li, M. Ziats, C. Ernst, R. Jaenisch, S.J. Haggarty, and M. Sur. MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling. Molecular Psychiatry [doi: 10.1038/mp.2017.86], 2017.
- Banerjee, A., R.V. Rikhye, V. Breton-Provencher, X. Tang, C. Li, C.A. Runyan, Z. Fu, R. Jaenisch and M. Sur. Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett Syndrome. Proceedings of the National Academy of Sciences 113: E7287-E7296, 2016.
- Goard, M.J., G.N. Pho, J. Woodson and M. Sur. Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions. e-Life 5: e13764. [doi: http://dx.doi.org/ 10.7554/eLife.13764], 2016.
- Sahin, M. and M. Sur. Genes, circuits and precision therapies for autism and related neurodevelopmental disorders. Science 350: 926 [doi: 10.1126/science.aab3897], 2015.
- Chen, N., H. Sugihara and M. Sur. An acetylcholine-activated microcircuit drives temporal dynamics of cortical activity. Nature Neuroscience 18: 892-902, 2015.